Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

R65.11 (“Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction”) is a diagnosis code that identifies a specific condition, injury, or finding on a medical claim in the ICD-10-CM code set. Whether it is billed — and whether a payer covers it — depends on the clinical setting, documentation, and plan rules.